If you know… you know.
Luxury has a waitlist—
and in the world of skincare, La Grande Crème is it.


Ultra-exclusive, clinically advanced, and always in demand, La Grande Crème by Biologique Recherche is the product we cannot keep on our shelves. That’s why we special order it just for our VIP clients who know it’s worth the wait.
Paired with Le Grand Sérum, this power duo is what we call the Birkin & Kelly of skincare—prestigious, powerful, and reserved for those who want nothing but the best.
Why They're Always in High Demand
Both La Grande Crème and Le Grand Sérum are not mass-produced; they are meticulously crafted and often available only through special order. Their exclusivity and proven efficacy make them highly sought-after, leading to frequent sell-outs. At Windermere Medical Spa & Laser Institute, we prioritize freshness and authenticity, ensuring that each product is sourced directly from Biologique Recherche upon request.

La Grande Crème: The Pinnacle of Anti-Aging Innovation
La Grande Crème is a groundbreaking formulation that addresses all age-related skin concerns. Infused with EpigenActiv®, it acts on the expression of genes involved in the skin aging process, promoting genuine cellular regeneration. Its active ingredients enhance the functional architecture of elastin and collagen fibers, delivering a real "lifting" and anti-wrinkle effect.
Key Benefits:
- Cellular Regeneration: Stimulates skin's natural renewal processes.
- Firming & Lifting: Improves skin elasticity and reduces wrinkles.
- Even Skin Tone: Reduces dark spots and promotes a radiant complexion.
- Protective Barrier: Strengthens skin's defense against environmental aggressors.
This cream is a favorite among celebrities like Demi Moore, who incorporates it into her nightly skincare routine to maintain her youthful glow.

Le Grand Sérum: The Ultimate Finishing Elixir
Le Grand Sérum is Biologique Recherche's most potent serum, boasting the highest concentrations of active ingredients among all their serums. This sublimating elixir was originally crafted for Madame Allouche, the co-founder of Biologique Recherche, embodying the brand's commitment to excellence.
Key Benefits:
- Age-Defying Performance: Enhances skin's self-defense against aging.
- Radiant Complexion: Illuminates and revitalizes dull, fatigued skin.
- Hydration & Protection: Maintains optimal moisture levels and shields skin from environmental stressors.
- Universal Application: Suitable for all skin types and conditions.
This serum is a staple in the skincare regimens of many celebrities and beauty enthusiasts, known for delivering visible results that intensify with each use.
Your Skin Deserves a Special Order
Experience the transformative power of Biologique Recherche's most esteemed products. Due to their exclusive nature, we recommend reserving your La Grande Crème and Le Grand Sérum in advance.